MyBioSource.com's TOB1 (Phospho-Ser164) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The TOB1 (Phospho-Ser164) Antibody was generated using APRO6, and Tob1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.Matsuda S., Oncogene 12:705-713(1996).Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases